C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2364590
This invention relates to newly identified prostate or prostate cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "prostate cancer antigens", and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such prostate cancer antigens for detection, prevention and treatment of disorders of the prostate, particularly the presence of prostate cancer. This invention relates to the prostate cancer antigens as well as vectors, host cells, antibodies directed to prostate cancer antigens and recombinant and synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the prostate, including prostate cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of prostate cancer antigens of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and/or function of the polypeptides of the present invention.
L'invention porte sur des polynucléotides et les polypeptides codés par eux nouvellement identifiés connus sous l'appellation collective d'"antigènes du cancer de la prostate", sur les séquences complètes de gènes leur étant associées, sur leurs produits d'expression, ainsi que sur l'utilisation desdits "antigènes du cancer de la prostate" pour la détection, la prévention et le traitement d'affections de la prostate dont en particulier le cancer de la prostate. L'invention porte sur les antigènes du cancer de la prostate ainsi que sur des vecteurs, des cellules hôtes, et des anticorps des antigènes de la prostate, et sur des procédés de recombinaison et de synthèse permettant de les produire. L'invention porte également sur des méthodes de diagnostic permettant de diagnostiquer, traiter, prévenir et/ou pronostiquer les affections de la prostate dont le cancer de la prostate, et sur des procédés thérapeutiques permettant de les traiter. L'invention porte en outre sur des procédés de criblage permettant d'identifier les agonistes et antagonistes des antigènes du cancer de la prostate de l'invention, et sur des procédés et/ou compositions inhibant la production et/ou la fonction des polypeptides de l'invention.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
Rosen Craig A.
LandOfFree
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