Human protein kinase hoacf72

Details Human protein kinase hoacf72 Human protein kinase hoacf72

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2223020

hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodefiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction, hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

On divulgue des polypeptides et polynucléotides de hYAK1 et des méthodes pour produire ces polypeptides par les techniques de recombinaison. On divulgue également des méthodes pour utiliser les polypeptides et polynucléotides de hYAK1 dans la conception de protocoles pour le traitement de la perte osseuse dont l'ostéoporose; les maladies inflammatoires comme le syndrome de détresse respiratoire aiguë de l'adulte, la polyarthrite rhumatoïde, l'ostéoarthrite, la maladie intestinale inflammatoire, le psoriasis, la dermatite, l'asthme; les allergies; les infections comme les infections bactériennes, fongiques, protozoaires et virales, particulièrement les infections causées par le VIH-1 ou le VIH-2; la cachexie liée au VIH et les autres affections d'immunodéficience; le choc septique; la douleur; les blessures; les cancers; l'anorexie; la boulimie; la maladie de Parkinson; les maladies cardio-vasculaires comme la resténose; l'athérosclérose, l'insuffisance cardiaque aiguë, l'infarctus du myocarde, l'hypotension; l'hypertension; la rétention urinaire; l'angine de poitrine; les ulcères; l'adénome prostatique; et les troubles psychotiques et neurologiques, dont l'anxiété, la schizophrénie, la maladie affective bipolaire, le délire, la démence, la déficience mentale grave et les dyskinésies, comme la chorée de Huntington ou le syndrome de Gilles de La Tourette, entre autres, et les épreuves diagnostiques pour ces affections.

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