Human protein kinases hyak3

Details Human protein kinases hyak3 Human protein kinases hyak3

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2231046

hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome., among others, and diagnostic assays for such conditions.

Sont décrits des polynucléotides et des polypeptides hYAK3 et des méthodes de production de ces polypeptides au moyen de techniques de l'ADN recombinant. Sont également décrites des méthodes d'utilisation des polynucléotides et des polypeptides hYAK3 dans la conception de protocoles de traitement de la perte osseuse, notamment l'ostéoporose; les maladies inflammatoires comme l'insuffisance respiratoire aiguë (IRA), la polyarthrite rhumatoïde, l'arthrose, les maladies intestinales inflammatoires, le psoriasis, la dermatite de contact, l'asthme, les allergies; les infections, telles que les infections bactériennes, fongiques, les protozooses et les infections virales, en particulier les infections causées par le VIH-1 ou le VIH-2; la cachexie liée au VIH et d'autres déficits immunitaires; le choc septique; la douleur; les blessures; les cancers, y compris le cancer du testicule; l'anorexie; la boulimie; la maladie de Parkinson; les maladies cardio-vasculaires, notamment la resténose, l'athérosclérose, l'insuffisance cardiaque aiguë, l'infarctus du myocarde; l'hypotension; l'hypertension; la rétention urinaire; l'angine de poitrine; les ulcères; l'hypertrophie prostatique bénigne; les troubles psychotiques et neurologiques, notamment l'anxiété, la schizophrénie, la maladie affective bipolaire, le délire aigu, la démence, le retard mental grave et les dyskinésies, comme la maladie de Huntington ou la maladie de Gilles de La Tourette, entre autres, et les tests diagnostiques pour ces affections.

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