Human protein scaffold with controlled serum pharmacokinetics

Details Human protein scaffold with controlled serum pharmacokinetics Human protein scaffold with controlled serum pharmacokinetics

A - Human Necessities

61

K

A61K 38/17 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2757897

This invention provides constructs comprising a protein scaffold, wherein the scaffold comprises Domain III, Domain IIIa, or Domain IIIb of human serum albumin or a polypeptide having substantial sequence identity to the Domain III, the Domain IIIa, or the Domain IIIb; and a targeting moiety in covalent linkage to the protein scaffold; and a therapeutic moiety and/or an imaging moiety in covalent linkage to the protein scaffold. The scaffold can be modified to tune the serum pharmacokinetics of the construct. In addition to methods of making the constructs, therapeutic, imaging and diagnostic uses of the constructs are also provided.

La présente invention concerne des produits de synthèse comprenant un squelette protéique, le squelette contenant le domaine III, le domaine IIIa ou le domaine IIIb de la sérumalbumine humaine ou un polypeptide possédant une séquence sensiblement identique au domaine III, au domaine IIIa ou au domaine IIIb; un fragment de vectorisation lié par liaison covalente au squelette protéique; et un fragment thérapeutique et/ou un fragment pour l'imagerie lié par liaison covalente au squelette protéique. Le squelette peut être modifié pour adapter la pharmacocinétique sérique du produit de synthèse. En plus des procédés de préparation des produits de synthèse, l'utilisation thérapeutique, diagnostique et en imagerie des produits de synthèse est également décrite.

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