Human protein which binds to human tyrosine kinase hck, and...

Details Human protein which binds to human tyrosine kinase hck, and... Human protein which binds to human tyrosine kinase hck, and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2389062

Novel proteins having an activity of binding to human tyrosine kinase Hck. These proteins are typified by those having the amino acid sequences represented by SEQ ID NO:1 or 12. Nucleic acids encoding these proteins. These proteins bind to human tyrosine kinase Hck and promote apoptosis caused by the stimulus by tumor lethal factor.

L'invention concerne des nouvelles protéines présentant la particularité de se lier à la tyrosine kinase humaine Hck. Ces protéines sont notamment caractérisées par celles qui comportent des séquences d'acides aminés représentées par SEQ ID NO 1 ou 12. L'invention concerne également des acides nucléiques codant pour ces protéines. Celles-ci se lient à la tyrosine kinase humaine Hck et favorisent l'apoptose liée au stimulus produit par le facteur létal tumoral.

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