Human proteins having secretory signal sequences and cdnas...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2305337

The invention provides human proteins having secretory signal sequences and DNAs coding for these proteins as well as eucaryotic cells forming said proteins by secretory expression. All of the proteins are secreted outside the cells and exist in the extracellular liquid or on the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals or as antigens for preparing antibodies against said proteins. Furthermore, said DNAs can be utilized for expression of said proteins in large amounts. Eucaryotic cells wherein expression vectors of said cDNAs are introduced can be utilized for secretory production of the proteins encoded by said cDNAs.

Cette invention concerne des protéines humaines comportant des séquences de signaux sécrétoires et des ADN codant ces protéines ainsi que des cellules eucaryotes formant lesdites protéines par expression sécrétoire. Toutes les protéines sont sécrétées à l'extérieur des cellules et existent dans le liquide extracellulaire ou sur la membrane cellulaire, c'est la raison pour laquelle on les considère comme des protéines contrôlant la prolifération et la différenciation des cellules. Par conséquent, les protéines peuvent être utilisées en tant que substances pharmaceutiques ou en tant qu'antigènes pour préparer des anticorps dirigés contre lesdites protéines. En outre, les ADN peuvent être utilisés pour l'expression desdites protéines en grandes quantités. Les cellules eucaryotes dans lesquelles les vecteurs d'expression desdits ADNc sont introduits peuvent être utilisées pour la production sécrétoire des protéines codées par lesdits ADNc.

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