C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2315240
The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and methods for discovering molecules which are useful in detecting and/or modulating the activation and/or conjugation of NEDD8. The present invention arises from the purification and characterization of novel NEDD8 activating and conjugating enzymes.
L'invention porte sur la modification covalente des protéines par leur conjugaison à d'autres protéines. Plus spécifiquement, l'invention porte sur la modulation de la conjugaison de la protéine NEDD8. L'invention porte également sur des compositions et des procédés de détection et/ou de modulation de l'activation et/ou de la conjugaison de NEDD8, ainsi que sur des compositions et des procédés permettant de rechercher les molécules qui sont utiles dans la détection et/ou la modulation de l'activation et/ou la conjugaison de NEDD8. Cette invention résulte de la purification et de la caractérisation des nouvelles enzymes d'activation et de conjugaison des protéines NEDD8.
Mbm Intellectual Property Law Llp
Millennium Pharmaceuticals Inc.
Proscript Inc.
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