Human prourokinase variants, methods of producing same, dna...

Details Human prourokinase variants, methods of producing same, dna... Human prourokinase variants, methods of producing same, dna...

C - Chemistry, Metallurgy

12

N

195/39, 195/1.22

C12N 15/58 (2006.01) C12N 1/00 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2017178

ABSTRACT OF THE DISCLOSURE A human prourokinase variant derived from human prourokinase by modifying the latter so that an amino acid sequence (I) of the formula Asn-X-Y (I) wherein X is any amino acid residue and Y is Ser or Thr, occurs in the epidermal growth factor domain thereof which shows a half life in blood significantly longer as compared with known human PUK and urokinase and comparable to that of the human PUK variant deficient in the whole EGF domain.

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