Human receptor proteins; related reagents and methods

Details Human receptor proteins; related reagents and methods Human receptor proteins; related reagents and methods

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2289912

Nucleic acids encoding nine human receptors, designated DNAX Toll-like receptors 2-10 (DTLR2-10), homologous to the Drosophila Toll receptor and the human IL-1 receptor, purified DTLR proteins and fragments thereof, mono- /polyclonal antibodies against these receptors, and methods for diagnostic and therapeutic use.

L'invention, qui a trait à des acides nucléiques codant neuf récepteurs humains désignés comme récepteurs 2-10 DNAX du type Toll (DTLR2-10), concerne également des homologues du récepteur de la mouche drosophile Toll et du récepteur humain de l'interleukine 1, des récepteurs protéiques DTLR purifiés et leurs fragments ainsi que des anticorps, tant monoclonaux que polyclonaux, contre ces récepteurs. Elle prote, de surcroît, sur des techniques diagnostiques et thérapeutiques.

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