Human recombinant beta-interferon with improved solubility

Details Human recombinant beta-interferon with improved solubility Human recombinant beta-interferon with improved solubility

C - Chemistry, Metallurgy

12

N

C12N 15/22 (2006.01) A61K 38/21 (2006.01) C07K 14/565 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2287521

The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu (5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(l16), Leu(120) and Phe(156) are exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.

L'invention concerne des variantes de l'interféron- beta humain recombiné, ainsi qu'un procédé permettant de le préparer, selon lequel au moins un des aminoacides suivants Leu(5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120), ainsi que Leu(156) sont échangés contre des aminoacides hydrophiles avec un groupe hydroxy, notamment sérine, tyrosine ou thréonine, ce qui augmente l'hydrophilité de la surface de la protéine.

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