Human relaxin formulation

Details Human relaxin formulation Human relaxin formulation

C - Chemistry, Metallurgy

07

K

167/103.46

C07K 14/64 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/38 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1336403

A pharmaceutical composition is provided wherein human relaxin is formulated at an acidic pH of about 4 to less than about 7. The composition, useful for effecting parturition and inhibiting premature delivery, includes a buffer capable of maintaining the pH of the composition within a desired range, and may also include an agent to make the composition isotonic, and a stabilizing agent, if necessary. A specific example is human relaxin formulated in a citrate buffer, pH about 5.0, in the presence of sodium chloride, at an ionic strength of about 0.15 µ.

591933

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