C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2097705
2097705 9210506 PCTABS00013 A human protein molecule termed H13 has strong sequence homology to murine retrovirus receptor proteins and encodes a human retrovirus receptor. DNA encoding the H13 protein, cells transformed and transfected with this DNA and antibodies specific for H13 are disclosed. The H13 protein or its functional derivative can be used for preventing or treating retrovirus infection by administration to a subject of the H13 protein or a functional derivative thereof, or an anti-H13 antibody. Transgenic animals, useful as animal models for diagnosis or therapy of human retrovirus infections, are made by transfecting embryonic cells with the H13-encoding DNA. A chimeric retrovirus receptor protein comprises the H13 sequence, having substituted therein, amino acid residues encoding a murine retroviral receptor. Expression of the chimeric receptor in human cells allows infection or retrovirus-mediated gene transfer with murine retroviruses, which provides an extra measure of safety for in vivo gene therapy. DNA encoding the chimeric retrovirus receptor protein, cells transformed with this DNA, and methods for rendering a cell susceptible to infection by a retrovirus normally incapable of infecting that cell are disclosed.
Meruelo Daniel
Yoshimoto Takayuki
Gowling Lafleur Henderson Llp
New York University
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