Human rrp sequences and methods of use

Details Human rrp sequences and methods of use Human rrp sequences and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2416445

Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.

Cette invention se rapporte à des protéines apparentées au gène rhomboïde (RRP), impliquées dans la voie de signalisation du récepteur du facteur de croissance épidermique (EGFR). Cette invention concerne également des mammifères non humains transgéniques, contenant un transgène codant un polypeptide RRP ou un gène produisant l'expression d'un polypeptide RRP, ainsi que des procédés servant à moduler l'interaction de protéines RRP avec leurs membres de voie, et des procédés de criblage d'agents qui modulent l'interaction d'un polypeptide RRP avec une cible de fixation de RRP, telle que des anticorps spécifiques de RRP et des petites molécules identifiées dans des cribles de rendement élevé. Des agents de modulation identifiés à l'aide de ces procédés peuvent servir à inhiber spécifiquement la croissance de cellules tumorales qui produisent une surexpression de protéine RRP.

Affiliated with

Also associated with

Rating

Human rrp sequences and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human rrp sequences and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human rrp sequences and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1737015