C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2400595
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides; antibodies that bind to NRG1 polypeptides; methods of diagnosis of susceptibility to schizophrenia; assays for agents that alter the activity of NRG1 polypeptide or which identify NRG1 binding agents, and the agents or binding agents identified by the assays; NRG1 therapeutic agents, including the NRG1 nucleic acids, NRG1 polypeptides, or agents that alter the activity of an NRG1 polypeptides; pharmaceutical compositions comprising the NRG1 therapeutic agents; as well as methods of therapy of schizophrenia.
L'invention concerne des acides nucléiques contenant le gène de la neuréguline 1 (NRG1) et codant les polypeptides NRG1. L'invention concerne également des acides nucléiques associés codant les polypeptides NRG1; les polypeptides NRG1; des anticorps se fixant aux polypeptides NRG1; des méthodes de diagnostic d'une prédisposition à la schizophrénie; des dosages pour des agents modifiant l'activité du polypeptide NRG1 ou lesquels identifient des agents fixant NRG1, ainsi que les agents ou agents fixants identifiés par les dosages; des agents thérapeutiques à NRG1, y compris les acides nucléiques NRG1; les polypeptides NRG1 ou des agents modifiant l'activité des polypeptides NRG1; des compositions pharmaceutiques contenant les agents thérapeutiques à NRG1; de même que des méthodes de thérapie de la schizophrénie.
Gulcher Jeffrey R.
Stefansson Hreinn
Steinthorsdottir Valgerdur
Decode Genetics Ehf
Gowling Lafleur Henderson Llp
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