Human sdf-5 protein and compositions

Details Human sdf-5 protein and compositions Human sdf-5 protein and compositions

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2279575

Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.

L'invention porte sur des protéines SDF-5 humaines purifiées et leur procédé d'obtention, et sur des molécules d'ADN codant pour elles. Lesdites protéines peuvent servir pour réguler la fixation des gènes Wnt à leurs récepteurs. Dans la variante préférée, ces protéines servent à induire la formation, la croissance, la différenciation, la prolifération et/ou l'entretien des tissus de chondrocytes et/ou cartilagineux, et à réparer d'autres tissus tels que les tissus du pancréas.

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