C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2239835
SDR2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SDR2 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflammation, cerebellar degeneration, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern baldness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.
Polypeptides SDR2 et polynucléotides et méthodes de production de ces polypeptides par des techniques de recombinaison. L'invention concerne également des méthodes d'utilisation des polypeptides SDR2 et des polynucléotides dans l'élaboration de protocoles pour le traitement de diverses affections : cancer, inflammation, maladies auto-immunes, allergie, asthme, polyarthrite rhumatoïde, inflammation du SNC, atrophie cérébelleuse, maladie d'Alzheimer, maladie de Parkinson, sclérose en plaques, sclérose latérale amyotrophique, traumatisme crânien et autres anomalies neurologiques, choc septique, accident vasculaire cérébral, ostéoporose, arthrose, phénomène d'ischémie/reperfusion, maladie cardio-vasculaire, néphropathie, hépatopathie, trouble ischémique, infarctus du myocarde, hypotension, hypertension, sida, syndromes myélodysplasiques et autres anomalies hématologiques, anémie aplasique, calvitie hippocratique, et infections bactériennes, fongiques, virales et protozooses, entre autres, et épreuves diagnostiques pour ces affections.
Albone Earl Francis
Kikly Kristine Kay
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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