Human semaphorin l (h-semal) and corresponding semaphorins...

Details Human semaphorin l (h-semal) and corresponding semaphorins... Human semaphorin l (h-semal) and corresponding semaphorins...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2237158

Human semaphorin L (H-SemaL) and corresponding semaphorins in other species. The invention relates to novel semaphorins which are distinguished by aparticular domain structure and derivatives thereof, nucleic acids (DNA, RNA, cDNA) which code for these semaphorins, and derivatives thereof, and the use thereof. The present invention relates to semaphorins which have a novel, as yetundisclosed and unexpected domain structure and which possess a biochemical function in the immune system (immunomodulating semaphorins). The novel semaphorins are referred to as type L semaphorins (Sema-L). They comprise an N-terminal signal peptide, a characteristic Sema domain and, in the C-terminal region of the protein, an immunoglobulin-like domain and a hydrophobic domain which represents a potential transmembrane domain.

Sémaphorine L humaine (SémaL-H) et sémaphorines correspondantes chez d'autres espèces. L'invention porte sur de nouvelles sémaphorines qui se distinguent par un domaine à structure particulière, sur leurs dérivés, sur les acides nucléiques (ADN, ARN, ADNc) codant ces sémaphorines et leurs dérivés, enfin sur leurs applications. La présente invention porte sur des sémaphorines possédant une structure de domaine, nouvelle, imprévue et inédite, ainsi qu'une fonction biochimique dans le système immunitaire (sémaphorines immunomodulatrices). Les nouvelles sémaphorines sont appelées sémaphorines de type L (Séma-L). Elles comprennent un peptide signal à N terminal, un domaine Séma caractéristique et, dans la région C-terminale de la protéine, un domaine de type immunoglobuline et un domaine hydrophobe, qui représente un domaine transmembranaire potentiel.

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