Human serum albomin fusion polypeptide

Details Human serum albomin fusion polypeptide Human serum albomin fusion polypeptide

C - Chemistry, Metallurgy

12

N

530/13, 195/1.34

C12N 15/62 (2006.01) C07K 14/49 (2006.01) C07K 14/495 (2006.01) C07K 14/73 (2006.01) C07K 14/755 (2006.01) C07K 14/765 (2006.01) C07K 14/78 (2006.01) C07K 14/81 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/81 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2015687

A fusion polypeptide comprising, as at least part of the N-terminal portion thereof, an N-terminal portion of human serum albumin (HSA) or a variant thereof and, as at least part of the C-terminal portion thereof, another polypeptide except that, when the said N-terminal portion of HSA is the 1-n portion where n is 369 to 419 or a variant thereof then the said polypeptide is one of various specified entities, including the 585 to 1578 portion of human fibronectin or a variant thereof. The HSA-like portion may have additional N- terminal residues, such as secretion leader sequences (signal sequences). The C- terminal portion is preferably the 585-1578 portion of human plasma fibronectin. The N-terminal and C-terminal portions may be cleavable to yield the isolated C- terminal portion, with the N-terminal portion having served to facilitate secretion from the host.

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