Human serum albumin and process for producing the same

Details Human serum albumin and process for producing the same Human serum albumin and process for producing the same

C - Chemistry, Metallurgy

12

N

C12N 15/14 (2006.01) C07K 1/36 (2006.01) C07K 14/765 (2006.01)

Patent

CA 2116385

ABSTRACT OF THE DISCLOSURE Human serum albumin obtained by gene manipulation techniques can be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.3 M, or treating the culture supernatant with boric acid or a salt thereof at pH 8 to 11 for 1 to 10 hours and recovering the supernatant to thereby obtain human serum albumin which contains substantially no contaminants which are contained in the culture medium or contained in or secreted by the host microorganism, specifically free nonantigenic contaminants detectable by the phenol-sulfuric acid method, antigenic producer host-derived contaminants and pyrogen. The thus- obtained human serum albumin is of very high purity and free from various side effects attributed to the contaminants. - 36 -

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