Human serum albumin fragment

C - Chemistry – Metallurgy – 12 – N

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530/13, 195/40,

C12N 15/14 (2006.01) A61K 38/38 (2006.01) C07K 14/765 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341298

Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. HSA (1-387) is particularly preferred, although not novel per se. The polypeptides may be produced by recombinant DNA techniques, especially in yeast.

580789

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