C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01N 63/00 (2006.01) A61K 35/36 (2006.01) A61K 38/57 (2006.01) A61P 17/02 (2006.01) C07K 14/81 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2600177
The present invention relates generally to compositions for wound healing. More specifically, the present invention provides human skin equivalents engineered to express exogenous proteinase inhibitor polypeptides (e.g., TIMP- 1 polypeptides) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
La présente invention a trait de manière générale à des compositions de guérison de plaies. Plus spécifiquement, cette invention concerne des substituts de peau humaine modifiés pour exprimer des polypeptides d'inhibiteur de protéinase (par exemple des polypeptides TIMP-1) et des compositions et procédés de production de substituts de peau humaine mis au point pour exprimer des polypeptides exogènes. En outre, la présente invention concerne des procédés de traitement de plaies à l~aide de substituts de peau humaine modifiés pour exprimer des polypeptides exogènes.
Allen-Hoffmann B. Lynn
Ivarie Cathy Ann-Rasmussen
Thomas Virnig Christina L.
Smart & Biggar
Stratatech Corporation
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