Human skin equivalents expressing exogenous polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A61K 35/36 (2006.01) A61K 48/00 (2006.01) A61P 5/00 (2006.01) A61P 17/02 (2006.01) A61P 31/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2534349

The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

La présente invention concerne de manière générale des compositions de fermeture de plaies. Plus spécifiquement, la présente invention concerne des équivalents de peau humaine modifiés pour exprimer des polypeptides exogènes (par exemple, des polypeptides antimicrobiens et un facteur de croissance des kératinocytes 2) ainsi que des compositions et des méthodes de production d'équivalents de peau humaine modifiés pour exprimer des polypeptides exogènes. En outre, la présente invention concerne des méthodes de traitement de plaies à l'aide d'équivalents de peau humaine modifiés pour exprimer des polypeptides exogènes.

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