Human sodium channel scn12a and scn8a

Details Human sodium channel scn12a and scn8a Human sodium channel scn12a and scn8a

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2412306

A novel .alpha. subunit SCN12A of the sodium channel of the human nervous system; its splicing variant SNC12A-s; another human sodium channel subunit SCN8A; human genes encoding these molecules; and cDNAs of these genes. SCN12A has the amino acid sequence of SEQ ID NO:2 and is encoded by a polynucleotide (cDNA) having the base sequence of SEQ ID NO:1. SCN12A-s has the amino acid sequence of SEQ ID NO:4 and is encoded by a polynucleotide (cDNA) having the base sequence of SEQ ID NO:3. SCN8A has the amino acid sequence of SEQ ID NO:6 and is encoded by a polynucleotide (cDNA) having the base sequence of SEQ ID NO:5.

Cette invention concerne une sous-unité .alpha. SCN12A du canal sodium du système nerveux humain ; sa variante d'épissage SNC12A-s ; une autre sous-unité SNC8A du canal sodium humain ; des gènes humains codant pour ces molécules ; et des ADNc des ces gènes. SNC12A, dont la séquence d'acides aminés est SEQ ID NO :1, est codé par un polynucléotide (ADNc) dont la séquence de base est SEQ ID NO :1. SNC12A-s, dont la séquence d'acides aminés est SEQ ID NO :4, est codé par un polynucléotide (ADNc) dont la séquence de base est<i> </i>SEQ ID NO :3. SNC8A, dont la séquence d'acides aminés est SEQ ID NO:6, est codé par un polynucléotide (ADNc) dont la séquence de base est<i> </i>SEQ ID NO : 3<i>.</i>

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