C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01)
Patent
CA 2749864
The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD 146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.
La présente invention porte sur des compositions et sur des procédés de modulation de l'angiogenèse in vivo, ex vivo ou in vitro. Plus particulièrement, l'invention porte sur une protéine CD146 soluble utilisable dans le contexte d'une thérapie humaine, ainsi que sur des anticorps correspondants. Des formes particulières de CD146, décrites présentement, peuvent être utilisées pour mobiliser, in vivo ou ex vivo, des cellules endothéliales tant matures qu'immatures, ainsi que pour augmenter leur influence sur l'angiogenèse. L'invention porte également sur des compositions comprenant de tels composés, en particulier sur des compositions pharmaceutiques ou diagnostiques, dont des trousses et similaires, ainsi que sur des méthodes thérapeutiques ou diagnostiques mettant en uvre lesdits composés, lesdites compositions et lesdites cellules.
Bardin Nathalie
Blot-Chabaud Marcel
Dignat-George Francoise
Guillet Benjamin
Harhouri Karim
Inserm (institut National de La Sante Et de La Recherche Medical
Smart & Biggar
Universite de La Mediterranee
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