Human sperm specific lysozyme-like proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 16/40 (2006.01) C12N 9/36 (2006.01) C12N 15/56 (2006.01)

Patent

CA 2397896

The present invention relates to two novel, testis-specific proteins (C19 and C23) that are lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the design of contraceptive agents. The C19 and C23 proteins can also be modified to establish lysozyme activity and the modified proteins can then be used in all applications that currently exist for lysozymes.

L'invention concerne deux nouvelles protéines, spécifiques des testicules, à savoir C19 et C23, lesquelles sont des paralogues du lysozyme. On pense que ces protéines jouent un rôle dans la capacitation du sperme et dans la fertilisation de l'ovule. Aussi, ces composés constituent-ils des cibles idéales pour la mise au point d'agents contraceptifs. On peut également modifier les protéines C19 et C23 pour établir l'activité du lysozyme et on peut utiliser ces protéines modifiées dans toutes les applications existant actuellement pour les lysozymes.

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