Human stanniocalcin-alpha

Details Human stanniocalcin-alpha Human stanniocalcin-alpha

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 31/70 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2203654

A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of electrolyte disorders which lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use therapeutically to treat hypocalcemia and osteoporosis are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to detect diseases or the susceptibility to diseases related to a mutated form of stanniocalcin-alpha sequences is also disclosed.

On décrit le polypeptide de stanniocalcine-alpha humaine et l'ADN (ARN) codant ce polypeptide, ainsi qu'un procédé pour le préparer par des techniques de recombinaison. On décrit également des procédés pour utiliser ce polypeptide dans le traitement de dérèglements affectant les électrolytes et conduisant à des maladies rénales, cardiaques et osseuses, comme par exemple l'ostéoporose et la maladie de Paget. On décrit également des antagonistes contre ces polypeptides et leur utilisation pour traiter l'hypocalcémie et l'ostéoporose. On décrit aussi l'utilisation de la séquence stanniocalcine-alpha comme agent diagnostique pour détecter des maladies ou des risques de maladies liés à une forme mutée de séquences de la stanniocalcine-alpha.

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