C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 31/711 (2006.01) A61K 35/76 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 17/00 (2006.01) A61P 17/10 (2006.01) A61P 17/14 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2339748
This invention provides a nucleic acid molecule encoding human stearoyl-CoA desaturase, and isolated protein encoded thereby. This invention also provides a method of diagnosing a human subject for a skin disorder characterized by an abnormal level of stearoyl-CoA desaturase expression. This invention further provides a method for determining whether an agent increases the expression level of human stearoyl-CoA desaturase in skin cells already expressing same. This invention further provides methods for determining whether an agent increases or decreases the expression level or activity of human stearoyl-CoA desaturase in skin cells already expressing same. This invention still further provides pharmaceutical compositions for treating human skin disorders characterized by abnormal stearoyl-CoA desaturase expression and/or activity, and related methods of treatment. Finally, this invention provides related antibodies, gene therapy vectors, and transgenic mice.
La présente invention concerne une molécule d'acide nucléique codant la stéaroyl-CoA désaturase humaine, et une protéine codée par ladite molécule. L'invention concerne aussi un procédé permettant de diagnostiquer chez un sujet humain des affections cutanées caractérisées par un niveau d'expression anormal de la stéaroyl-CoA désaturase. L'invention concerne également un procédé permettant de déterminer si un agent augmente le niveau d'expression de lastéaroyl-CoA désaturase dans des cellules cutanées qui l'expriment déjà, ainsi qu'un procédé permettant de déterminer si un agent augmente au abaisse le niveau d'expression ou l'activité de la stéaroyl-CoA désaturase dans des cellules cutanées qui l'expriment déjà. On décrit des compositions pharmaceutiques destinées à traiter des affections cutanées caractérisées par un niveau d'expression et/ou d'activité anormal de la stéaroyl-CoA désaturase, ainsi que des procédés de traitement associés. L'invention concerne en outre des anticorps associés, des vecteurs de thérapie génique et des souris transgéniques.
Parimoo Satish
Prouty Stephen M.
Stenn Kurt
Zhang Lin
Johnson & Johnson Consumer Companies Inc.
Smart & Biggar
LandOfFree
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