C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) C12N 9/22 (2006.01)
Patent
CA 2318374
Novel synthetic suppressor tRNA have been provided which provide read-through of internal nonsense mutations, or which can site-specifically alter translation of transcribed sequences. Uses of the same are also provided in genetic engineering protocols including gene therapy treatment of diseases such as Xeroderma pigmentosum.
La présente invention concerne un ARNt de synthèse suppresseur permettant la lecture de mutations non sens, ou capables de modifier de façon spécifique au site la traduction des séquences transcrites. L'invention concerne également l'utilisation de cet ARNt de synthèse suppresseur pour des protocoles de génie génétique, y compris le traitement par thérapie génique d'affections telles que Xeroderma pigmentosum.
Link Charles J. Jr.
Panchal Rekha G.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Human Gene Therapy Research Institute
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