Human telomerase reverse transcriptase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2267664

The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

La présente invention se rapporte à des compositions et à des procédés relatifs à la transcriptase inverse de la télomérase humaine (hTRT human telomerase reverse transcriptase), la sous-unité protéique catalytique de la télomérase d'origine humaine. Les polynucléotides et les polypeptides de la présente invention s'avèrent utiles s'agissant du diagnostic, du pronostic et du traitement de certaines maladies humaines, ils servent à modifier la capacité de prolifération de cellules et d'organismes, et à identifier et à analyser des composés et des traitements adaptés à des maladies telles que les cancers.

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