C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2287782
The present invention relates to the cloning of a novel cDNA sequence encoding the theta receptor subunit of the GABAA receptor; to stably co-transfected eukaryotic cell lines capable of expressing a GABAA receptor, which receptor comprises the novel theta receptor subunit; and to the use of such cell lines in screening for and designing medicaments which act upon the GABAA receptor.
La présente invention concerne le clonage d'une nouvelle séquence d'ADN complémentaire codant la sous-unité de récepteur thêta du récepteur de GABA¿A?; l'invention concerne également des lignées cellulaires eucaryotes co-transfectées de manière stable, capables d'exprimer un récepteur de GABA¿A?, ledit récepteur comprenant la nouvelle sous-unité de récepteur thêta; l'invention concerne enfin l'utilisation de ces lignées cellulaires dans le criblage et la conception de médicaments ayant un effet sur le récepteur de GABA¿A?.
Bonnert Timothy Peter
Whiting Paul John
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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