Human thymosin .beta.15 gene, protein and uses thereof

Details Human thymosin .beta.15 gene, protein and uses thereof Human thymosin .beta.15 gene, protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257855

The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin .beta. family. This novel protein, herein referred to as thymosin .beta.15, has the ability to bind and sequester G- actin, like other members of the thymosin .beta. family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is directed to an isolated cDNA encoding the human thymosin .beta.15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).

Les présents inventeurs ont découvert que les êtres humains possèdent un gène qui code une nouvelle protéine de la famille des thymosines .beta.. Cette nouvelle protéine, appellée ici thymosine .beta.15, a la capacité de fixer et de séquestrer la G-actine, tout comme les autres membres de la famille des thymosines .beta., mais, à la différence de ce que l'on sait sur ces autres membres, cette nouvelle protéine a également le pouvoir de réguler directement la motilité cellulaire dans les cellules des carcinomes de la prostate. Cette invention concerne un ADNc isolé codant ce gène de la thymosine .beta.15 humain (SEQ ID NO: 1) et ayant déduit la séquence d'acides aminés (SEQ ID NO: 2).

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