Human timp-1 antibodies

Details Human timp-1 antibodies Human timp-1 antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/38 (2006.01) C07K 16/40 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2445168

Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.

L'invention concerne des anticorps humains se liant à TIMP-1 et pouvant être utilisés en tant que réactifs pour diagnostiquer et traiter des troubles dans lesquels TIMP-1 est élevé, tels qu'une fibrose du foie, des maladies du foie liées à l'alcool, une fibrose cardiaque, un syndrome coronaire aigu, une néphropathie lupique, une maladie rénale glomérulosclérotique, une hypertrophie bénigne de la prostate, un cancer du colon, un cancer du poumon, et une fibrose pulmonaire idiopathique.

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