Human tissue plasminogen activator variants and processes

Details Human tissue plasminogen activator variants and processes Human tissue plasminogen activator variants and processes

C - Chemistry, Metallurgy

12

N

195/1.13, 195/1.

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C12N 15/00 (2006.01) C12N 15/58 (2006.01) C12N 15/63 (2006.01)

Patent

CA 1341612

Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.

594301

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