C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.22, 195/1.
C12N 15/00 (2006.01) C12N 9/06 (2006.01) C12N 9/72 (2006.01) C12N 15/85 (2006.01)
Patent
CA 1271149
ABSTRACT A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.
445592
Levinson Arthur D.
Simonsen Christian C.
Yelverton Elizabeth M.
Genentech Inc.
Johnson Douglas S. Q.c.
Levinson Arthur D.
Simonsen Christian C.
Yelverton Elizabeth M.
LandOfFree
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