Human tryptase-like protein

Details Human tryptase-like protein Human tryptase-like protein

C - Chemistry, Metallurgy

12

N

167/130, 167/140

C12N 9/76 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2025630

ABSTRACT OF THE DISCLOSURE Novel human tryptase-like protein having both trypsin-like and chymotrypsin-like activity specifically binds with anti-rat tryptase antibody and comprises two subunits of about 35+3 KDa and four subunits of about 30+2 KDa. The human tryptase-like protein can be obtained from human acute lymphoblastic leukemia cell line, Molt 4. The anti-human tryptase-like protein antibody strongly inhibits HIV infection, which is indicated by a potent inhibition of syncytia formation. Pharmaceutical compositions comprising the anti-human tryptase-like protein antibody are effective for the treatment of AIDS.

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