Human tumor-associated thomsen-friedenreich antigen

Details Human tumor-associated thomsen-friedenreich antigen Human tumor-associated thomsen-friedenreich antigen

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2072866

2072866 9106865 PCTABS00005 A heterologous sandwich immunoassay has been developed for human TF antigen using a monoclonal antibody as the catcher and labelled peanut agglutinin as the probe. Since human TF antigen is shed by tumor cells, a positive determination of the TF antigen in a patient sample indicates the presence of cancer. The test can also be used to monitor the course of conventional chemotherapy or radiotherapy by monitoring the amount of TF antigen in a fluid sample from a patient being so treated. Because of the sensitivity of the assay method, cancer can be detected in very early stages by the assay method of the present invention.

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