Human tumor necrosis factor

C - Chemistry – Metallurgy – 12 – N

Patent

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530/13, 195/1.22

C12N 15/28 (2006.01) C07K 14/525 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341348

A human physiologically active polypeptide, human Tumor Necrosis Factor (human TNF), comprising a specific amino acid sequence of 155 amino acid residues. The base sequence of the DNA coding for the human TNF has been determined using rabbit TNF cDNA. The human TNF can be advantageously produced on a large scale by recombinant DNA technique. The human TNF of the present invention has been found to be excellent in inducing necrosis of tumours with no toxic effect upon the a normal tissues of the living body.

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