Human tumor necrosis factor receptor-like 2 (tr2) antibodies

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2290067

The present invention relates to antibodies to novel members of the Tumor Necrosis Factor (TNF) receptor family called TR2 receptor and their uses in pathological conditions. Hybridoma cell lines producing such mAbs, methods of in vivo imaging of pathological conditions, and methods of treating and diagnosing pathological conditions, caused by abnormal functioning, production or metabolism of TR2 receptors are also provided. In vitro assays for detecting the presence of TR2 and for evaluating the binding affinity of a test compound are also described.

La présente invention concerne des anticorps dirigés contre de nouveaux membres de la famille des récepteurs du facteur de nécrose des tumeurs (TNF) appelés récepteurs TR2 et leur utilisations dans des états pathologiques. L'invention concerne également des lignées de cellules d'hybridomes produisant de tels anticorps monoclonaux, des méthodes d'imagerie in vivo d'un état pathologique, et des méthodes thérapeutiques et diagnostiques concernant les états pathologiques provoqués par un fonctionnement, une production ou un métabolisme anormal des récepteurs TR2. L'invention concerne enfin des analyses in vitro permettant de détecter la présence de TR2 et d'évaluer l'affinité de liaison d'un composé analysé.

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