Human tumor necrosis factor receptor tr9

Details Human tumor necrosis factor receptor tr9 Human tumor necrosis factor receptor tr9

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2365255

The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

Cette invention concerne un nouveau membre de la famille des récepteurs des facteurs de nécrose des tumeurs, en particulier des molécules isolées d'acides nucléiques codant pour le récepteur TR9 humain. L'invention concerne également des poylypeptides en tant que vecteurs et cellules hôtes ainsi que des méthodes recombinantes permettant d'obtenir lesdits vecteurs et cellules hôtes. De plus, elle concerne des méthodes de recherche systématique d'agonistes et d'antagonistes de l'activité du récepteur TR9.

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