Human type 3 ryanodine receptor protein and dna molecules...

Details Human type 3 ryanodine receptor protein and dna molecules... Human type 3 ryanodine receptor protein and dna molecules...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291960

The invention relates to nucleic acids and a human type 3 (hRyRe) ryanodine receptor, chimeric ryanodine receptors with fractions of the human receptor and to a method for the production of said proteins. The invention also relates to the detection of ryanodine receptors in human tissue to diagnose pathological states and to methods for identifying hRyRe activators or inhibitors.

L'invention concerne des acides nucléiques et une protéine du récepteur humain de la ryanodine du type 3 (hRyR3), des récepteurs chimériques de la ryanodine avec des fractions du récepteur humain, ainsi que des procédés pour la fabrication de cette protéine. L'invention concerne également la détection de récepteurs de la ryanodine dans les tissus humains en vue du diagnostic d'états pathologiques, et des procédés pour identifier des activateurs ou des inhibiteurs du hRyR3.

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