C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2561901
Association of Type II diabetes and a locus on chromosome 5 is disclosed. In particular, the gene KChIP 1 within this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those who have Type II diabetes or are at risk of developing Type II diabetes, in particular those that are non-obese are described.
La présente invention a trait à la correspondance entre le diabète de type II et un site sur le chromosome 5. En particulier, une analyse de liaison fait apparaître que le gène KchIP se trouvant au sein de ce site est un gène de prédisposition au diabète de type II. L'invention a trait au ciblage de voies pour l'administration de médicaments et des applications diagnostiques dans l'identification de personnes souffrant du diabète de type II ou sont à risque de développer le diabète de type II, notamment des personnes non obèses.
Grant Struan F.
Gulcher Jeffrey R.
Reynisdottir Inga
Thorleifsson Gudmar
Decode Genetics Ehf.
Gowling Lafleur Henderson Llp
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