Human type ii diabetes gene-kv channel-interacting protein...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 6/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2501523

Association of Type II diabetes and a locus on chromosome 5 is disclosed. In particular, the gene KCh1P 1 within this locus is shown by linkage analysis to be a susceptibility gene for Type Il diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those who have Type lI diabetes or are at risk of developing Type Il diabetes, in particular those that are non-obese are described.

L'invention concerne une correspondance entre le diabète de type II et un site sur le chromosome 5. En particulier, une analyse de liaison fait apparaître que le gène KCh1P 1 situé dans ce site est un gène de prédisposition pour le diabète de type Il. Sont décrites le ciblage de voies d'administration de médicaments et des applications diagnostiques pour des personnes souffrant d'un diabète de type II ou risquant de contracter un diabète de type II, en particulier des personnes non obèses.

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