Human type ii diabetes gene-slit-3 located on chromosome 5q35

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2501514

Association of Type II diabetes and a locus on chromosome 5q35 is disclosed. In particular, the gene SLIT-3 within this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those have Type II diabetes or at risk of developing Type II diabetes, in particular those that are non- obese are described.

La présente invention se rapporte à l'association entre le diabète du type II et un locus situé sur le chromosome 5q35. De manière plus particulière, le gène SLIT-3 présent dans ce locus est déterminé, par analyse de liaison, comme étant un gène de susceptibilité au diabète de type II. Cette invention concerne également le ciblage de la voie pour des applications d'apport de médicament et de diagnostic permettant d'identifier les sujets atteints du diabète de type II ou risquant de développer un diabète de type II, notamment les sujets ne souffrant pas d'obésité.

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