C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/805 (2006.01) A61K 38/42 (2006.01) C07K 1/107 (2006.01)
Patent
CA 2225881
The present inventions describes a method to cross-link human hemoglobin obtained from umbilical cord red blood cells. Cross-linked cord blood hemoglobin is a mixture of adult and fetal hemoglobins but it has the same molecular weight distribution and oxygen delivery capability as does cross-linked purified adult hemoglobin. For example, unpurified cord blood hemoglobin cross-linked by O-raffinose has the same P50, Hill Coefficient, oxygen saturation and molecular weight distribution as cross-linked highly purified adult hemoglobin. Cross-linked cord blood hemoglobin may therefore substitute for cross-linked adult hemoglobin in any use as an hemoglobin-based oxygen carrier. This method does not require the prior separation of fetal and adult hemoglobins from cord blood before cross-linking. Other methods of cross-linking, polymerizing or otherwise stabilizing cell-free purified or unpurified cord blood hemoglobins may serve equally well as HBOCs. Cross-linked cord blood hemoglobin may have additional uses as an HBOC that depend upon some of the unique structural and functional characteristics of fetal hemoglobin. Discarded umbilical cord blood provides a large source of hemoglobin for use as an HBOC.
Bell David
Hemosol Inc.
Ridout & Maybee Llp
LandOfFree
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