Human vascular endothelial growth factor 3

Details Human vascular endothelial growth factor 3 Human vascular endothelial growth factor 3

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224002

Disclosed is a human VEGF3 polypeptide and DNA (RNA) encoding such VEGF3 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF3 coding sequence and alterations in the concentration of VEGF3 protein in a sample derived from a host are also disclosed.

L'invention concerne un polypeptide VEGF3 humain ainsi que l'ADN (ARN) codant ce type de polypeptides VEGF3. L'invention concerne également une procédure de production d'un tel polypeptide par des techniques de recombinaison ainsi que des anticorps et des antagonistes actifs vis-à-vis d'un tel polypeptide. L'invention concerne en outre un procédé d'utilisation d'un tel polypeptide dans le but d'accélérer la cicatrisation et de réparer des tissus vasculaires. L'invention concerne également des procédés d'utilisation desdits antagonistes pour inhiber la croissance des tumeurs, l'inflammation et pour traiter la rétinopathie diabétique, la polyarthrite rhumatoïde et le psoriasis. L'invention concerne en outre des procédés de diagnostic permettant de déceler des mutations dans la séquence de codage des VEGF3, de même que des modifications de la concentration de la protéine VEGF3 dans un échantillon prélevé sur un sujet hôte.

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