Human vegf-specific antisense oligonucleotides

Details Human vegf-specific antisense oligonucleotides Human vegf-specific antisense oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) C12N 15/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2214431

Disclosed are oligonucleotides complementary to VEGF-specific nucleic acid useful in reducing the expression of VEGF. Also disclosed are pharmaceutical formulations containing such oligonucleotides and method useful for treating various disorders associated with neovascularization and angiogenesis.

L'invention concerne des oligonucléotides complémentaires de l'acide nucléique spécifique du facteur de croissance de l'endothélium vasculaire utiles dans la réduction de l'expression dudit facteur de croissance. L'invention concerne également des formulations pharmaceutiques contenant ces oligonucléotides et un procédé utile pour traiter divers troubles associés à la néoformation de vaisseaux sanguins et à l'angiogénèse.

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