Human zip1, zinc and citrate for prostate cancer screening

Details Human zip1, zinc and citrate for prostate cancer screening Human zip1, zinc and citrate for prostate cancer screening

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 16/28 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/84 (2006.01) G01N 23/223 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2637934

The present invention provides methods of detecting prostate cancer employing biomarkers, including hZIPl, zinc and citrate. Also provided are antibodies to detect hZIPl protein or peptides and an expression vector comprising a genetic sequence effective to increase uptake of zinc into a prostate cell upon expression thereof. Furthermore, methods of treating prostate cancer and of increasing uptake of zinc into a prostate cell are provided.

La présente invention concerne des procédés de détection d~un cancer de la prostate utilisant des biomarqueurs, dont le zinc, le citrate et hZIP1. L'invention concerne également des anticorps permettant de détecter des peptides ou une protéine hZIP1 et un vecteur d~expression comprenant une séquence génétique efficace en termes d~augmentation de la capture du zinc au sein d~une cellule prostatique lors de son expression. Par ailleurs, l~invention concerne des procédés de traitement du cancer de la prostate et d~augmentation de la capture du zinc au sein d~une cellule prostatique.

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