C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 11/00 (2006.01) A61P 37/06 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2680344
This invention relates to humaneered anti-factor B antibodies and antigen-binding fragments thereof with reduced immunogenicity. The humaneered anti-factor B antibodies and antigen- binding fragments thereof are derived from murine monoclonal antibody 1379, which binds factor B in the third short consensus repeat ("SCR") domain and selectively inhibits activation of the alternative complement pathway by preventing formation of the C3bBb complex. The invention also relates to methods of treating diseases or disorders in which activation of the alternative complement pathway plays a role, and methods of selectively inhibiting activation of the alternative complement pathway in an individual in need thereof.
La présente invention concerne des anticorps anti-facteur B humanisés et leurs fragments d'immunogénicité réduite. Les anticorps anti-facteur B humanisés et leurs fragments sont dérivés de l'anticorps monoclonal de souris 1379, qui lie le facteur B dans le troisième domaine de la séquence consensuelle répétée (SCR) et empêche de façon sélective l'activation de la voie alterne en prévenant la formation du complexe C3bBb. L'invention se rapporte en outre à des procédés permettant de traiter les maladies ou les troubles dans lesquels l'activation de la voie alterne joue un rôle, ainsi qu'à des procédés permettant d'empêcher de façon sélective l'activation de la voie alterne chez un individu en ayant le besoin.
Emlen Woodruff
Flynn Peter
Holers V. Michael
Heenan Blaikie Llp
Taligen Therapeutics Inc.
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