Humanised and chimeric monoclonal antibodies

Details Humanised and chimeric monoclonal antibodies Humanised and chimeric monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/16 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082160

The invention relates to new humanized monoclonal antibody comprising an artificial modified consensus sequence at least of the FRs of the heavy chain variable region of a human immunoglobulin. The invention relates, furthermore, to corre- sponding humanized and chimeric monoclonal antibodies which are binding to epitopes of the Epidermal Growth Factor wher- ein the responsible hypervariable regions have the following amino acid sequence: light chain:CDR-1: -Ser-Ala-Ser-Ser-Ser-Val- Thr-Tyr-Met-Tyr-; CDR-2: -Asp-Thr-Ser-Asn-Leu-Ala-Ser-; CDR-3: -Gln-Gln-Trp- Ser-Ser-His-Ile-Phe-Thr-; heavy chain: CDR-1: -Ser-His-Trp-Met-His-; CDR-2: -Glu-Phe-Asn-Pro-Ser-Asn-Gly-Arg-Thr-Asn- Glu-Lys-Phe-Lys-Ser-; CDR-3: -Arg- Asp-Tyr-Asp-Tyr-Asp-Gly-Arg-Tyr-Phe-Asp-Tyr-. The antibodies can be used for therapeutical and diagnostic purposes.

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