Humanised antibodies

Details Humanised antibodies Humanised antibodies

C - Chemistry, Metallurgy

12

N

530/13, 167/139,

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2037607

CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions 6, 23 and/or 24, 48 and/or 49, 71 and/or 73, 75 and/or 76 and/or 78 and 88 and/or 91. The CDR-graftd light chains comprise donor residues at at least one of positions 1 and/or 3 and 46 and/or 47 or at at least one of positions 46, 48, 58 and 71. The CDR-grafted antibodies are preferably humanised antibodies, having non human, e.g. rodent, donor and human acceptor frameworks, and may be used for in vivo therapy and diagnosis. A generally applicable protocol is disclosed for obtaining CDR-grafted antibodies.

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